2,3-Dihydro-5-methoxy-1,4-benzodioxin

Base Information

• Chemical Name: 2,3-Dihydro-5-methoxy-1,4-benzodioxin
• CAS No.: 1710-55-0
• Molecular Formula: C9H10 O3
• Molecular Weight: 166.177
• Hs Code.: 2932999099
• European Community (EC) Number: 216-972-6
• DSSTox Substance ID: DTXSID70168984
• Nikkaji Number: J203.098E
• Wikidata: Q83038606
• Mol file: 1710-55-0.mol

Synonyms:2,3-Dihydro-5-methoxy-1,4-benzodioxin;1710-55-0;5-methoxy-2,3-dihydro-1,4-benzodioxine;EINECS 216-972-6;5-methoxy-2,3-dihydrobenzo[b][1,4]dioxine;5-methoxybenzo-1,4-dioxane;5-Methoxy-1,4-benzodioxane;SCHEMBL6837924;DTXSID70168984;MFCD00517354;SY308746

Chemical Property of 2,3-Dihydro-5-methoxy-1,4-benzodioxin

Chemical Property:

• Vapor Pressure: 0.0613mmHg at 25°C
• Boiling Point: 239.6°Cat760mmHg
• Flash Point: 78.2°C
• PSA: 27.69000
• Density: 1.167g/cm³
• LogP: 1.46640
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

1,4-BENZODIOXIN, 2,3-DIHYDRO-5-METHOXY- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC2=C1OCCO2

Technology Process of 2,3-Dihydro-5-methoxy-1,4-benzodioxin

There total 3 articles about 2,3-Dihydro-5-methoxy-1,4-benzodioxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-methocycatechol (934-00-9) + ethylene dibromide (106-93-4) → 5-methoxy-2,3-dihydrobenzo[b][1,4]dioxane (1710-55-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 6h; Inert atmosphere;

DOI:10.1021/op1001287

Reference yield: 64.2%

3-methocycatechol (934-00-9) → 5-methoxy-2,3-dihydrobenzo[b][1,4]dioxane (1710-55-0)

Guidance literature:

In 2,3-dihydro-8-methoxy-1,4-benzodioxine-5-carboaldehyde;

Reference yield:

→ 5-methoxy-2,3-dihydrobenzo[b][1,4]dioxane (1710-55-0)

Guidance literature:

upstream raw materials:

3-methocycatechol

ethylene dibromide

Downstream raw materials:

cis-4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid

5-bromo-8-methoxy-2,3-dihydrobenzo[b][1,4]dioxine

2,3-dihydro-1,4-benzodioxin-5-ol

Refernces

• 1、 -. "Aromatic ring dioxane quinazoline or quinoline compound, composition and application of aromatic ring dioxane quinazoline or quinoline compound". Paragraph 0086-0087. . Retrieved 2020/06/09.
• 2、 -. "Derivatives of benzofuran or benzodioxole". . . Retrieved 2008/06/13.