tert-butyl (2S)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]propanoate

Base Information

Chemical Name:tert-butyl (2S)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]propanoate
CAS No.:1401228-03-2
Molecular Formula:C₂₇H₂₈F₂N₂O₄S
Molecular Weight:514.593
Hs Code.:

Synonyms:tert-butyl (2S)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]propanoate

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Chemical Property of tert-butyl (2S)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]propanoate

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Technology Process of tert-butyl (2S)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]propanoate

There total 2 articles about tert-butyl (2S)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 41369-60-2
N-(p-toluenesulfonylmethyl)-p-toluenesulfonamide

: N-[bis(4-fluorophenyl)methylene]glycine tert-butyl ester

: 1401228-03-2
tert-butyl (2S)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]propanoate

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; caesium carbonate; In tetrahydrofuran; at -20 ℃; for 12h; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2cc35160a

Reference yield:

: 70-55-3
toluene-4-sulfonamide

: 1401228-03-2
tert-butyl (2S)-2-{[bis(4-fluorophenyl)methylidene]amino}-3-[(4-methylbenzene)sulfonamido]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / water / 24 h / 0 - 20 °C

2: (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; tetrakis(actonitrile)copper(I) hexafluorophosphate; caesium carbonate / tetrahydrofuran / 12 h / -20 °C / Inert atmosphere

With formic acid; tetrakis(actonitrile)copper(I) hexafluorophosphate; (Rp)-2-(tert-butylthio)-1-(diphenyl-phosphino)ferrocene; caesium carbonate; In tetrahydrofuran; water; 1: |Mannich Aminomethylation / 2: |Mannich Aminomethylation;
DOI:10.1039/c2cc35160a