(E)-N'-(pyridin-2-yl)cinnamic hydrazide

Base Information

• Chemical Name: (E)-N'-(pyridin-2-yl)cinnamic hydrazide
• CAS No.: 1208362-03-1
• Molecular Formula: C₁₄H₁₃N₃O
• Molecular Weight: 239.277
• Mol file: 1208362-03-1.mol

Synonyms:(E)-N'-(pyridin-2-yl)cinnamic hydrazide

Chemical Property of (E)-N'-(pyridin-2-yl)cinnamic hydrazide

Chemical Property:

Purity/Quality:

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Technology Process of (E)-N'-(pyridin-2-yl)cinnamic hydrazide

There total 1 articles about (E)-N'-(pyridin-2-yl)cinnamic hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-chloropyridine (109-09-1) + (E)-3-phenylacryloylhydrazide (3538-69-0) → (E)-N'-(pyridin-2-yl)cinnamic hydrazide (1208362-03-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-(-)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; chemoselective reaction;

DOI:10.1021/ol902868q

Reference yield: 93.0%

(E)-N'-(pyridin-2-yl)cinnamic hydrazide (1208362-03-1) → 3-[(E)-2-phenylethenyl][1,2,4]triazolo[4,3-a]pyridine (1208362-02-0)

Guidance literature:

With acetic acid; at 180 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/ol902868q

upstream raw materials:

2-chloropyridine

(E)-3-phenylacryloylhydrazide

Downstream raw materials:

3-[(E)-2-phenylethenyl][1,2,4]triazolo[4,3-a]pyridine

Refernces