3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)-1-(3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)propan-1-one

Base Information

Chemical Name:3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)-1-(3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)propan-1-one
CAS No.:1190969-82-4
Molecular Formula:C₂₈H₃₇ClN₄O₅S
Molecular Weight:577.145
Hs Code.:

Synonyms:3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)-1-(3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)propan-1-one

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Chemical Property of 3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)-1-(3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)propan-1-one

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Technology Process of 3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)-1-(3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)propan-1-one

There total 10 articles about 3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)-1-(3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1021204-82-9
3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionic acid

: 1082328-64-0
C₁₂H₁₇N₃O₂

: 1190969-82-4
3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)-1-(3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)propan-1-one

Guidance literature:: 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

C₁₂H₁₇N₃O₂; With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 1190969-82-4
3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)-1-(3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 1.5 h / 20 °C

2.1: hydrogen / platinum(IV) oxide / methanol / 3 h / 4137.29 Torr

3.1: triethylamine / dichloromethane / 0 - 20 °C

3.2: 19 h

4.1: water; potassium hydroxide / methanol / 15 h / 20 °C

4.2: pH 4 / Cooling with ice

5.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

5.2: 20 °C

With water; hydrogen; triethylamine; 1,1'-carbonyldiimidazole; potassium hydroxide; platinum(IV) oxide; In methanol; dichloromethane; toluene;

Reference yield:

: 7340-23-0
ethyl 3-(pyridin-2-yl)acrylate

: 1190969-82-4
3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)-1-(3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / platinum(IV) oxide / methanol / 3 h / 4137.29 Torr

2.1: triethylamine / dichloromethane / 0 - 20 °C

2.2: 19 h

3.1: water; potassium hydroxide / methanol / 15 h / 20 °C

3.2: pH 4 / Cooling with ice

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

4.2: 20 °C

With water; hydrogen; triethylamine; 1,1'-carbonyldiimidazole; potassium hydroxide; platinum(IV) oxide; In methanol; dichloromethane;