(Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester

Base Information

Chemical Name:(Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester
CAS No.:85548-86-3
Molecular Formula:C₄₃H₇₂Cl₃NO₈SSi₂
Molecular Weight:925.643
Hs Code.:

(Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester

Synonyms:(Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester

Suppliers and Price of (Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester

There total 1 articles about (Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 85548-77-2
Methyl (5Z,13E,8S,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(dimethylamino)-8-(phenylsulfonyl)-5,13-prostadienoate

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 85548-86-3
(Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; at 25 ℃; for 120h;
DOI:10.1021/jo00161a010

Reference yield: 91.0%

: 85548-86-3
(Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester

: 85548-87-4
(Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid methyl ester

Guidance literature:: With zinc; In tetrahydrofuran; at 65 ℃; for 6h;
DOI:10.1021/jo00161a010

Reference yield:

: 85548-86-3
(Z)-7-{(1S,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[methyl-(2,2,2-trichloro-ethoxycarbonyl)-amino]-cyclopentyl}-hept-5-enoic acid methyl ester

: 363-24-6
dinoprostone

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / zinc powder / tetrahydrofuran / 6 h / 65 °C

2: 99 percent / sodium hydroxide / methanol; H₂O / 48 h

3: 83 percent / sodium carbonate, sodium tungstate, 40percent peracetic acid / H₂O; methanol

4: 91 percent / 1) sodium methoxide, 2) sodium borohydride / methanol / 1) -30 degC, 20min, 2) 25 degC, 6h

5: 84 percent / paraformaldehyde, boron trifluoride etherate / H₂O; acetone / 120 h / Ambient temperature

With peracetic acid; sodium hydroxide; sodium tetrahydroborate; sodium tungstate; formaldehyd; boron trifluoride diethyl etherate; sodium methylate; sodium carbonate; zinc; In tetrahydrofuran; methanol; water; acetone;
DOI:10.1021/jo00161a010