3-(3-hydroxypropyl)-2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione

Base Information

• Chemical Name: 3-(3-hydroxypropyl)-2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione
• CAS No.: 1353853-23-2
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 1353853-23-2.mol

Synonyms:3-(3-hydroxypropyl)-2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione

Chemical Property of 3-(3-hydroxypropyl)-2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(3-hydroxypropyl)-2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione

There total 2 articles about 3-(3-hydroxypropyl)-2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3-(2-methyl-5-(1-methylethyl)-3,6-dioxocyclohexa-1,4-dienyl)propanoic acid (1240724-54-2) → 3-(3-hydroxypropyl)-2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione (1353853-23-2)

Guidance literature:

3-(2-methyl-5-(1-methylethyl)-3,6-dioxocyclohexa-1,4-dienyl)propanoic acid; With sodium tetrahydroborate; iodine; In tetrahydrofuran; Reflux;

With methanol; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/cbdv.200900328

Reference yield: 32.0%

thymoquinone (490-91-5) + sodium 4-hydroxybutanoate (502-85-2) → 3-(3-hydroxypropyl)-2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione (1353853-23-2)

Guidance literature:

With ammonium peroxydisulfate; silver nitrate; In water; acetonitrile; for 16h; Inert atmosphere; Reflux;

DOI:10.1002/cmdc.201600594

Reference yield: 83.0%

3-(3-hydroxypropyl)-2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione (1353853-23-2) + artesunic acid (88495-63-0) → C32H44O10

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/cmdc.201600594

upstream raw materials:

3-(2-methyl-5-(1-methylethyl)-3,6-dioxocyclohexa-1,4-dienyl)propanoic acid

thymoquinone

sodium 4-hydroxybutanoate

Downstream raw materials:

3-[2-methyl-5-(1-methylethyl)-3,6-dioxocyclohexa-1,4-dienyl]propyl betulinate