8-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]isoquinoline hydrochloride

Base Information

Chemical Name:8-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]isoquinoline hydrochloride
CAS No.:1315571-55-1
Molecular Formula:C₂₂H₂₀F₃N₃O₃S*ClH
Molecular Weight:499.941
Hs Code.:

Synonyms:8-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]isoquinoline hydrochloride

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Chemical Property of 8-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]isoquinoline hydrochloride

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Technology Process of 8-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]isoquinoline hydrochloride

There total 2 articles about 8-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]isoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61563-43-7
isoquinoline-8-carboxylic acid

: 1204535-11-4
(3S)-3-methyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine

: 1315571-55-1
8-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]isoquinoline hydrochloride

Guidance literature:: isoquinoline-8-carboxylic acid; (3S)-3-methyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine; With N-ethylmorpholine;; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 74879-18-8
(S)-2-methylpiperazine

: 1315571-55-1
8-[((2S)-2-methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1-piperazinyl)carbonyl]isoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran / 1.17 h / 0 °C

2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethylmorpholine; / N,N-dimethyl-formamide

With N-ethylmorpholine;; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;