tert-butyl 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-1-oxo-2,9-diazaspiro[5.5]-undecane-9-carboxylate

Base Information

Chemical Name:tert-butyl 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-1-oxo-2,9-diazaspiro[5.5]-undecane-9-carboxylate
CAS No.:1313237-12-5
Molecular Formula:C₂₃H₃₁N₅O₃
Molecular Weight:425.531
Hs Code.:

Synonyms:tert-butyl 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-1-oxo-2,9-diazaspiro[5.5]-undecane-9-carboxylate

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Chemical Property of tert-butyl 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-1-oxo-2,9-diazaspiro[5.5]-undecane-9-carboxylate

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Technology Process of tert-butyl 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-1-oxo-2,9-diazaspiro[5.5]-undecane-9-carboxylate

There total 5 articles about tert-butyl 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-1-oxo-2,9-diazaspiro[5.5]-undecane-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1313237-25-0
2-(2-(bromomethyl)phenyl)-2H-1,2,3-triazole

: 1198284-94-4
tert-butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate

: 1313237-12-5
tert-butyl 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-1-oxo-2,9-diazaspiro[5.5]-undecane-9-carboxylate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 5h;

Reference yield:

: 5159-41-1
2-iodobenzyl alcohol

: 1313237-12-5
tert-butyl 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-1-oxo-2,9-diazaspiro[5.5]-undecane-9-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / N,N-dimethyl-formamide / 0.42 h / 120 - 160 °C / microwave

2: phosphorus tribromide / tetrahydrofuran / 0.33 h / 70 °C

3: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 5 h / 0 - 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1313237-23-8
(2-(2H-1,2,3-triazol-2-yl)phenyl)methanol

: 1313237-12-5
tert-butyl 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-1-oxo-2,9-diazaspiro[5.5]-undecane-9-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus tribromide / tetrahydrofuran / 0.33 h / 70 °C

2: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 5 h / 0 - 20 °C

With phosphorus tribromide; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil;