N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-cyclopropaneacetamide

Base Information

Chemical Name:N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-cyclopropaneacetamide
CAS No.:1394908-05-4
Molecular Formula:C₂₅H₃₃N₃O₂
Molecular Weight:407.556
Hs Code.:

Synonyms:N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-cyclopropaneacetamide

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Chemical Property of N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-cyclopropaneacetamide

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Technology Process of N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-cyclopropaneacetamide

There total 5 articles about N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-cyclopropaneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1394909-44-4
5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzenemethanamine

: 5239-82-7
cyclopropylacetic acid

: 1394908-05-4
N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-cyclopropaneacetamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1394909-43-3
5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)-benzonitrile

: 1394908-05-4
N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-cyclopropaneacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; ammonia / Raney nickel / methanol / 14 °C

2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 20 °C

With ammonia; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; Raney nickel; In methanol; dichloromethane;

Reference yield:

: 325142-95-8
2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1394908-05-4
N-[[5-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-2-(2,6-dimethyl-4-pyridinyl)phenyl]methyl]-cyclopropaneacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

2: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1.5 h / 120 °C / Inert atmosphere; Sealed tube

3: hydrogen; ammonia / Raney nickel / methanol / 14 °C

4: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 20 °C

With ammonia; hydrogen; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; toluene;