Hyaluronan

Base Information

• Chemical Name: Hyaluronan
• CAS No.: 9067-32-7
• Deprecated CAS: 34448-35-6,1319723-90-4,1430231-35-8
• Molecular Formula: (C14H20NO11Na)n
• Molecular Weight: 403.31
• Hs Code.: 39139000
• European Community (EC) Number: 618-620-0
• Wikidata: Q27078001
• NCI Thesaurus Code: C83761
• RXCUI: 42892
• Mol file: 9067-32-7.mol

Synonyms:Acid, Hyaluronic;Amo Vitrax;Amvisc;Biolon;Etamucine;Healon;Hyaluronan;Hyaluronate Sodium;Hyaluronate, Sodium;Hyaluronic Acid;Hyvisc;Luronit;Sodium Hyaluronate;Vitrax, Amo

Chemical Property of Hyaluronan

Chemical Property:

• Appearance/Colour: solid
• Boiling Point: 791.6oC
• Flash Point: 432.5oC
• PSA: 399.71000
• Density: 1.78g/cm3
• LogP: -8.49480
• Storage Temp.: −20°C
• Solubility.: H2O: 5 mg/mL, clear, colorless
• Water Solubility.: SOLUBLE
• Hydrogen Bond Donor Count: 14
• Hydrogen Bond Acceptor Count: 23
• Rotatable Bond Count: 12
• Exact Mass: 799.22325494
• Heavy Atom Count: 54
• Complexity: 1300

Purity/Quality:

99-100% ^*data from raw suppliers

Hyaluronic acid sodium salt - Extra low molecular weight 8,000-15,000 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): B,Xi
• Hazard Codes: B,Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36/37/39-27-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)NC1C(C(C(OC1O)CO)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)C(=O)O)O)O)O)NC(=O)C)O)O.[Na+]
• Isomeric SMILES: CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)NC(=O)C)O)O.[Na+]
• Recent ClinicalTrials: HA35 Acute Alcohol Study
• Recent EU Clinical Trials: Multicentre, randomized, double-blind, parallel design clinical trial of efficacy, safety and tolerability of Xylometazoline + Sodium Hyaluronate nasal spray, compared to Xylometazoline, Sodium Hyaluronate and Placebo nasal sprays, in adolescent and adult patients with acute viral rhinosinusitis
• Biopolymer with High Water-Retaining Capacity: Sodium hyaluronate (SH) is a disaccharide belonging to the glycosaminoglycan biopolymers family. It exhibits a high water-retaining capacity, making it effective in managing ocular surface diseases like Dry Eye Disease (DED).
• Formulation as a Lubricant for Ocular Surface: SH combined with chondroitin sulfate (CS) provides viscoelastic and water retention properties to products like Humylub庐 Ofteno PF. This formulation acts as an effective lubricant, protecting the eye surface and reconstituting the tear film, particularly in DED patients. Preservative-free formulations like SH/CS-PF offer therapeutic options without the adverse effects of preservatives like benzalkonium chloride (BAK).
• Similarity to Natural Tears: SH, often used as artificial tears, shares a similar composition to natural tears. Its good viscosity allows it to stay on the ocular surface, lubricating it effectively.; Combining SH with fibrin accelerates the adhesion and extension of corneal epithelial cells, restoring tear film stability and alleviating dry eye symptoms.
• Effectiveness in Dry Eye Management: Post-cataract surgery, SH, along with conventional anti-inflammatory treatment, effectively improves dry eye symptoms and test results for dry eye.; SH acts primarily on the mucin layer of the tear film, contributing to its stability and delaying tear film tearing time.
• Biomedical Uses: Hyaluronan (NaHy), the sodium salt of hyaluronic acid, is a natural linear polysaccharide present in biologic fluids and tissues.; Due to its biocompatibility and biodegradability, HyA finds extensive applications in various medical and biomedical fields, including drug delivery, tissue engineering, and cosmetics.
• Clinical Effectiveness and Rheology: Differences in the molecular weight and rheology of SH in artificial tears impact its clinical effectiveness. Intra-blink viscosity decreases compared to inter-blink viscosity, enhancing in-eye retention and comfort.

Technology Process of Hyaluronan

There total 2 articles about Hyaluronan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrabutylammonium hyaluronate → sodium hyaluronate (9067-32-7)

Guidance literature:

tetrabutylammonium hyaluronate; In dimethyl sulfoxide; at 30 ℃; for 24h;

With sodium azide; In water; for 192h;

Reference yield:

hyaluronic acid (9004-61-9) → sodium hyaluronate (9067-32-7)

Guidance literature:

With sodium chloride; In water; for 24h;

Reference yield:

sodium hyaluronate (9067-32-7) → hyaluronic acid (9004-61-9)

Guidance literature:

upstream raw materials:

hyaluronic acid

Downstream raw materials:

hyaluronic acid, molecular weight 60000

hyaluronic acid, molecular weight 40000

hyaluronic acid

Refernces

• 1、 -. "EXTENDED RELEASE ANALGESIC FOR PAIN CONTROL". Page/Page column 3. . Retrieved 2008/06/13.