2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

Base Information

Chemical Name:2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one
CAS No.:1235480-74-6
Molecular Formula:C₃₃H₄₃N₃O₃Si
Molecular Weight:557.808
Hs Code.:

Synonyms:2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

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Chemical Property of 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

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Technology Process of 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

There total 5 articles about 2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1235480-73-5
3-(4-sec-butylphenyl)-2-(4-hydroxy-3,5-dimethylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1235480-74-6
2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

Guidance literature:: 3-(4-sec-butylphenyl)-2-(4-hydroxy-3,5-dimethylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

2-(tert-butyldimethylsilyloxy)ethyl bromide; In N,N-dimethyl-formamide; at 80 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1235480-71-3
acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester

: 1235480-74-6
2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid

2: potassium carbonate / methanol

3: caesium carbonate / N,N-dimethyl-formamide

With potassium carbonate; caesium carbonate; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1517/13543776.2011.548322

Reference yield:

: 1235480-72-4
acetic acid 4-[3-(4-sec-butyl-phenyl)-4-oxo-3,4-dihydro-pyrido[4,3,d]pyrimidin-2-yl]-2,6-dimethyl-phenyl ester

: 1235480-74-6
2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol

2: caesium carbonate / N,N-dimethyl-formamide

With potassium carbonate; caesium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1517/13543776.2011.548322