3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one
• CAS No.: 1235479-83-0
• Molecular Formula: C₂₇H₂₉N₃O₃
• Molecular Weight: 443.546
• Mol file: 1235479-83-0.mol

Synonyms:3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

Chemical Property of 3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

There total 6 articles about 3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one (1235480-74-6) → 3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one (1235479-83-0)

Guidance literature:

2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

With water; In ethyl acetate;

Reference yield:

acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester (1235480-71-3) → 3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one (1235479-83-0)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid

2: potassium carbonate / methanol

3: caesium carbonate / N,N-dimethyl-formamide

4: tetrabutyl ammonium fluoride / tetrahydrofuran

With tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1517/13543776.2011.548322

Reference yield:

acetic acid 4-[3-(4-sec-butyl-phenyl)-4-oxo-3,4-dihydro-pyrido[4,3,d]pyrimidin-2-yl]-2,6-dimethyl-phenyl ester (1235480-72-4) → 3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one (1235479-83-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / methanol

2: caesium carbonate / N,N-dimethyl-formamide

3: tetrabutyl ammonium fluoride / tetrahydrofuran

With tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1517/13543776.2011.548322

upstream raw materials:

2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester

acetic acid 4-[3-(4-sec-butyl-phenyl)-4-oxo-3,4-dihydro-pyrido[4,3,d]pyrimidin-2-yl]-2,6-dimethyl-phenyl ester

3-(4-sec-butylphenyl)-2-(4-hydroxy-3,5-dimethylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one