acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester

Base Information

• Chemical Name: acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester
• CAS No.: 1235480-71-3
• Molecular Formula: C₁₇H₁₄N₂O₄
• Molecular Weight: 310.309
• Mol file: 1235480-71-3.mol

Synonyms:acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester

Chemical Property of acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester

There total 3 articles about acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

acetic acid 4-chlorocarbonyl-2,6-dimethyl-phenyl ester (105578-34-5) + 4-aminonicotinic acid (7418-65-7) → acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester (1235480-71-3)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 40h; Inert atmosphere;

Reference yield:

3,5-dimethyl-4-acetoxybenzoic acid (23298-94-4) → acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester (1235480-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane

2: pyridine / dichloromethane

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1517/13543776.2011.548322

Reference yield:

3,5-dimethyl-4-hydroxybenzoic acid (4919-37-3) → acetic acid 2,6-dimethyl-4-(4-oxo-4H-pyrido[4,3-d][1,3]oxazin-2-yl)-phenyl ester (1235480-71-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / pyridine

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane

3: pyridine / dichloromethane

With pyridine; dmap; oxalyl dichloride; N,N-dimethyl-formamide; In pyridine; dichloromethane;

DOI:10.1517/13543776.2011.548322

upstream raw materials:

acetic acid 4-chlorocarbonyl-2,6-dimethyl-phenyl ester

4-aminonicotinic acid

3,5-dimethyl-4-hydroxybenzoic acid

3,5-dimethyl-4-acetoxybenzoic acid

Downstream raw materials:

acetic acid 4-[3-(4-sec-butyl-phenyl)-4-oxo-3,4-dihydro-pyrido[4,3,d]pyrimidin-2-yl]-2,6-dimethyl-phenyl ester

2-{4-[2-(tert-butyldimethylsilanyloxy)ethoxy]-3,5-dimethylphenyl}-3-(4-sec-butylphenyl)-3H-pyrido[4,3-d]pyrimidin-4-one

3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)pyrido[4,3-d]pyrimidin-4(3H)-one