5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one

Base Information

• Chemical Name: 5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one
• CAS No.: 127130-09-0
• Molecular Formula: C₁₉H₂₁N₃O₂S
• Molecular Weight: 355.461
• Mol file: 127130-09-0.mol

Synonyms:5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one

Chemical Property of 5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one

There total 3 articles about 5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(2-chloroethyl)dimethylamine hydrochloride (4584-46-7) + 2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one (127130-07-8) → 5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one (127130-09-0)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; for 72h; Ambient temperature;

DOI:10.1021/jo00301a025

Reference yield:

O-ethyl 4-methoxythiobenzoate (10602-66-1) → 5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one (127130-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, -75 deg C, 30 min 2.) dioxane, 4h reflux

2: 72 percent / t-BuOK / dimethylformamide / 72 h / Ambient temperature

With potassium tert-butylate; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1021/jo00301a025

Reference yield:

4-methoxy-benzimidic acid ethyl ester (829-48-1) → 5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one (127130-09-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂S, Dowex 50W-X₈ / methanol / -30 °C

2: 1.) LDA / 1.) THF, hexane, -75 deg C, 30 min 2.) dioxane, 4h reflux

3: 72 percent / t-BuOK / dimethylformamide / 72 h / Ambient temperature

With Dowex 50W-X₈; hydrogen sulfide; potassium tert-butylate; lithium diisopropyl amide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo00301a025

upstream raw materials:

(2-chloroethyl)dimethylamine hydrochloride

2-(4-methoxyphenyl)pyrido<2,3-b><1,5>thiazepin-4(5H)-one

O-ethyl 4-methoxythiobenzoate

4-methoxy-benzimidic acid ethyl ester