6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enecarboxylic acid ethyl ester

Base Information

• Chemical Name: 6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enecarboxylic acid ethyl ester
• CAS No.: 221124-24-9
• Molecular Formula: C₂₅H₃₂O₃Si
• Molecular Weight: 408.613
• Mol file: 221124-24-9.mol

Synonyms:6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enecarboxylic acid ethyl ester

Chemical Property of 6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enecarboxylic acid ethyl ester

There total 1 articles about 6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester (28469-52-5) + tert-butylchlorodiphenylsilane (58479-61-1) → 6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enecarboxylic acid ethyl ester (221124-24-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(01)00044-8

Reference yield:

n-butyl magnesium bromide (693-03-8) + chloro-trimethyl-silane (75-77-4) + 6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enecarboxylic acid ethyl ester (221124-24-9) → C32H50O3Si2

Guidance literature:

With Br₂Cu^(1-)*Li⁽¹⁺⁾; ammonium chloride; In tetrahydrofuran; at -10 ℃; Yield given;

DOI:10.1016/S0040-4039(98)02543-X

Reference yield:

6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enecarboxylic acid ethyl ester (221124-24-9) → (anti,syn) 2-(tert-butyl-diphenyl-silanyloxy)-6-n-butyl-cyclohexanecarboxylic acid ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: LiCuBr₂ / tetrahydrofuran / -10 °C

1.2: NH₄Cl / tetrahydrofuran; H₂O

2.1: 1.81 g / SiO₂ / hexane; CH₂Cl₂

With Br₂Cu^(1-)*Li⁽¹⁺⁾; silica gel; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1016/S0040-4020(01)00044-8

upstream raw materials:

6-hydroxy-cyclohex-1-enecarboxylic acid ethyl ester

tert-butylchlorodiphenylsilane