(S)-(-)-2-Amino-4-ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-pyrimidinecarboxamide

Base Information

Chemical Name:(S)-(-)-2-Amino-4-ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-pyrimidinecarboxamide
CAS No.:84332-40-1
Molecular Formula:C₁₄H₂₃N₅O₂
Molecular Weight:293.369
Hs Code.:
DSSTox Substance ID:DTXSID20233292
Nikkaji Number:J70.326E
Wikidata:Q83114746

Synonyms:5-Pyrimidinecarboxamide, 2-amino-4-ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-, (S)-(-);(S)-(-)-2-Amino-4-ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-pyrimidinecarboxamide;84332-40-1;DTXSID20233292;LS-134736;(?)-2-Amino-4-ethoxy-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-5-pyrimidinecarboxamide

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(-)-2-Amino-4-ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-pyrimidinecarboxamide

Chemical Property:

Density:1.162g/cm³
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:293.18517499
Heavy Atom Count:21
Complexity:341

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=CN=C(N=C2OCC)N
Isomeric SMILES:CCN1CCC[C@H]1CNC(=O)C2=CN=C(N=C2OCC)N

Technology Process of (S)-(-)-2-Amino-4-ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-pyrimidinecarboxamide

There total 5 articles about (S)-(-)-2-Amino-4-ethoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15400-53-0
ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate

: 84332-40-1
2-Amino-4-ethoxy-pyrimidine-5-carboxylic acid ((S)-1-ethyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / pyridine / 2 h / Heating

2: 81 percent / phosphorus oxychloride / 2 h / 60 °C

3: 93 percent / sodium / Ambient temperature

4: NaOH / methanol; H₂O / 1 h / 65 °C

5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp, overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In pyridine; methanol; water;

Reference yield:

: 72419-38-6
2-Amino-4-ethoxy-pyrimidine-5-carboxylic acid ethyl ester

: 84332-40-1
2-Amino-4-ethoxy-pyrimidine-5-carboxylic acid ((S)-1-ethyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp, overnight

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 344311-74-6
2-Acetylamino-4-hydroxy-pyrimidine-5-carboxylic acid ethyl ester

: 84332-40-1
2-Amino-4-ethoxy-pyrimidine-5-carboxylic acid ((S)-1-ethyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / phosphorus oxychloride / 2 h / 60 °C

2: 93 percent / sodium / Ambient temperature

3: NaOH / methanol; H₂O / 1 h / 65 °C

4: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp, overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In methanol; water;