2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine

Base Information

Chemical Name:2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine
CAS No.:1393837-06-3
Molecular Formula:C₂₁H₂₆N₂
Molecular Weight:306.451
Hs Code.:

Synonyms:2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine

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Chemical Property of 2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine

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Technology Process of 2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine

There total 7 articles about 2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393836-90-2
2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1393837-06-3
2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine

Guidance literature:: 2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 4h;

With sodium hydrogencarbonate; In ethyl acetate;

Reference yield:

: 15761-39-4,59433-50-0
N-tert-butoxycarbonyl-proline

: 1393837-06-3
2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -30 °C

1.2: -30 - 20 °C

2.1: silver(l) oxide / 2 h / 20 °C / Cooling with ice

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

4.2: -78 - 20 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C

6.1: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere; microwave

7.1: hydrogenchloride / 1,4-dioxane / 4 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; isobutyl chloroformate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; silver(l) oxide; DavePhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 813433-68-0
2-methoxycarbonylmethylpyrrolidine-1-carboxylic acid tert-butyl ester

: 1393837-06-3
2-[2-(((indan-2-yl)phenyl)amino)ethyl]pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

2.2: -78 - 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C

4.1: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere; microwave

5.1: hydrogenchloride / 1,4-dioxane / 4 h / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;