3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide

Base Information

Chemical Name:3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide
CAS No.:798543-63-2
Molecular Formula:C₁₇H₂₁N₃O₄
Molecular Weight:331.371
Hs Code.:

Synonyms:3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide

Chemical Property:

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Technology Process of 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide

There total 13 articles about 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 798543-65-4
3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester

: 798543-63-2
3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide

Guidance literature:: With hydroxylamine potassium salt; In methanol; at 0 ℃;
DOI:10.1002/cmdc.201300393

Reference yield:

: 93633-32-0
5-methoxy-2-methylene-5-oxopentanoic acid

: 798543-63-2
3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

2: Grubbs catalyst first generation / dichloromethane / 20 °C / Inert atmosphere; Darkness

3: hydroxylamine potassium salt / methanol / 0 °C

With Grubbs catalyst first generation; dmap; hydroxylamine potassium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1002/cmdc.201300393

Reference yield:

: 959931-17-0
C₁₈H₂₂N₂O₅

: 798543-63-2
3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-N-hydroxy-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: Grubbs catalyst first generation

2: acetic acid; zinc / methanol

3: dmap; TEA

4: KONH₂ / methanol

With dmap; TEA; acetic acid; zinc; Grubbs catalyst first generation; In methanol;
DOI:10.1016/j.bmcl.2007.09.034