3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester

Base Information

Chemical Name:3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester
CAS No.:798543-65-4
Molecular Formula:C₁₈H₂₂N₂O₄
Molecular Weight:330.384
Hs Code.:

Synonyms:3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester

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Chemical Property of 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester

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Technology Process of 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester

There total 12 articles about 3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93633-32-0
5-methoxy-2-methylene-5-oxopentanoic acid

: 798543-65-4
3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

2: Grubbs catalyst first generation / dichloromethane / 20 °C / Inert atmosphere; Darkness

With Grubbs catalyst first generation; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1002/cmdc.201300393

Reference yield:

: 959931-17-0
C₁₈H₂₂N₂O₅

: 798543-65-4
3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Grubbs catalyst first generation

2: acetic acid; zinc / methanol

3: dmap; TEA

With dmap; TEA; acetic acid; zinc; Grubbs catalyst first generation; In methanol;
DOI:10.1016/j.bmcl.2007.09.034

Reference yield:

: 7409-30-5
p-nitrobenzylamine

: 798543-65-4
3-[1-(4-acetylamino-benzyl)-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / Heating

2: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide

3: Grubbs catalyst first generation

4: acetic acid; zinc / methanol

5: dmap; TEA

With dmap; TEA; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; zinc; Grubbs catalyst first generation; In methanol;
DOI:10.1016/j.bmcl.2007.09.034