N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide

Base Information

Chemical Name:N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide
CAS No.:1380647-65-3
Molecular Formula:C₃₃H₃₃Cl₂F₆N₇O₃
Molecular Weight:760.567
Hs Code.:

N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide

Synonyms:N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide

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Chemical Property of N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide

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Technology Process of N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide

There total 14 articles about N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 461-82-5
4-(trifluoromethoxy)aniline

: 1380648-72-5
2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid

: 1380647-65-3
N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide

Guidance literature:: 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; for 0.5h;

4-(trifluoromethoxy)aniline; With pyridine; In dichloromethane; acetonitrile; at 40 - 60 ℃;

Reference yield:

: 1380648-66-7
6-methylamino-5-nitro-2-(4-trifluoromethyl-piperidinyl)-nicotinic acid ethyl ester

: 1380647-65-3
N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 6 h / 3102.97 Torr

2.1: acetonitrile

2.2: 3 h / 60 °C

3.1: sodium hydroxide; water / ethanol / 20 - 55 °C

3.2: pH ~ 5.5

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h

4.2: 40 - 60 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; water; hydrogen; sodium hydroxide; palladium on activated charcoal; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 657-36-3
4-Trifluormethyl-piperidin

: 1380647-65-3
N-(4-trifluoromethoxyphenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 3 h / 20 °C

1.2: 20 - 70 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 0.83 h / Reflux

2.2: 5 - 10 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 6 h / 3102.97 Torr

4.1: acetonitrile

4.2: 3 h / 60 °C

5.1: sodium hydroxide; water / ethanol / 20 - 55 °C

5.2: pH ~ 5.5

6.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h

6.2: 40 - 60 °C

With thionyl chloride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; water; hydrogen; triethylamine; sodium hydroxide; palladium on activated charcoal; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;