2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid

Base Information

Chemical Name:2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid
CAS No.:1380648-72-5
Molecular Formula:C₂₆H₂₉Cl₂F₃N₆O₃
Molecular Weight:601.456
Hs Code.:

2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid

Synonyms:2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid

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Chemical Property of 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid

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Technology Process of 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid

There total 13 articles about 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380648-70-3
2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid ethyl ester

: 1380648-72-5
2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid

Guidance literature:: 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid ethyl ester; With water; sodium hydroxide; In ethanol; at 20 - 55 ℃;

With potassium hydrogensulfate; In ethanol; water; pH=~ 5.5;

Reference yield:

: 657-36-3
4-Trifluormethyl-piperidin

: 1380648-72-5
2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 3 h / 20 °C

1.2: 20 - 70 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 0.83 h / Reflux

2.2: 5 - 10 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 6 h / 3102.97 Torr

4.1: acetonitrile

4.2: 3 h / 60 °C

5.1: sodium hydroxide; water / ethanol / 20 - 55 °C

5.2: pH ~ 5.5

With thionyl chloride; water; hydrogen; triethylamine; sodium hydroxide; palladium on activated charcoal; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1218944-66-1
2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinic acid

: 1380648-72-5
2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-5-[4-trifluoromethyl-piperidin-1-yl]-3-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide; acetonitrile / 3 h / 20 °C

1.2: 20 - 70 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 0.83 h / Reflux

2.2: 5 - 10 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 6 h / 3102.97 Torr

4.1: acetonitrile

4.2: 3 h / 60 °C

5.1: sodium hydroxide; water / ethanol / 20 - 55 °C

5.2: pH ~ 5.5

With thionyl chloride; water; hydrogen; triethylamine; sodium hydroxide; palladium on activated charcoal; N,N-dimethyl-formamide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;