(R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

Base Information

Chemical Name:(R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine
CAS No.:1526935-38-5
Molecular Formula:C₂₄H₃₃N₃O₄
Molecular Weight:427.544
Hs Code.:

Synonyms:(R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

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Technology Process of (R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

There total 11 articles about (R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1526935-41-0
(R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

: 1526935-38-5
(R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; under 3620.13 Torr;
DOI:10.1021/jm401384w

Reference yield:

: 124439-98-1
(R)-7-hydroxychroman-2-carboxylic acid ethyl ester

: 1526935-38-5
(R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane

2: lithium borohydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3: pyridine / 0 - 4 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide; 1,4-dioxane / 90 °C

5: palladium on activated charcoal; hydrogen / ethanol / 3620.13 Torr

With pyridine; lithium borohydride; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm401384w

Reference yield:

: 943035-30-1
4-(4-benzyloxyphenyl)piperazine-1-carboxylic acid tert-butyl ester

: 1526935-38-5
(R)-1-(4-hydroxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 40 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide; 1,4-dioxane / 90 °C

5: palladium on activated charcoal; hydrogen / ethanol / 3620.13 Torr

With hydrogenchloride; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm401384w