(R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

Base Information

Chemical Name:(R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine
CAS No.:1526935-41-0
Molecular Formula:C₃₁H₃₉N₃O₄
Molecular Weight:517.668
Hs Code.:

Synonyms:(R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

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Chemical Property of (R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

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Technology Process of (R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

There total 10 articles about (R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1526935-40-9
1-(4-benzyloxyphenyl)-4-(2-aminoethyl)piperazine

: 1526935-02-3
toluene-4-sulfonic acid, (R)-(7-(methoxymethoxy)chroman-2-yl)methyl ester

: 1526935-41-0
(R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dimethyl sulfoxide; at 90 ℃;
DOI:10.1021/jm401384w

Reference yield:

: 124439-98-1
(R)-7-hydroxychroman-2-carboxylic acid ethyl ester

: 1526935-41-0
(R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane

2: lithium borohydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3: pyridine / 0 - 4 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide; 1,4-dioxane / 90 °C

With pyridine; lithium borohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm401384w

Reference yield:

: 943035-30-1
4-(4-benzyloxyphenyl)piperazine-1-carboxylic acid tert-butyl ester

: 1526935-41-0
(R)-1-(4-benzyloxyphenyl)-4-(4-(7-(methoxymethoxy)chroman-2-yl)-3-azabutyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 40 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide; 1,4-dioxane / 90 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm401384w