(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-hydroxy-4-nitrophenyl)-2,4-pentadienamide

Base Information

Chemical Name:(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-hydroxy-4-nitrophenyl)-2,4-pentadienamide
CAS No.:1313740-72-5
Molecular Formula:C₁₈H₁₄N₂O₆
Molecular Weight:354.319
Hs Code.:

Synonyms:(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-hydroxy-4-nitrophenyl)-2,4-pentadienamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-hydroxy-4-nitrophenyl)-2,4-pentadienamide

Chemical Property:

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Technology Process of (2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-hydroxy-4-nitrophenyl)-2,4-pentadienamide

There total 5 articles about (2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-hydroxy-4-nitrophenyl)-2,4-pentadienamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 4711-72-2
piperic acid chloride

: 121-88-0
5-Nitro-2-aminophenol

: 1313740-72-5
(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-hydroxy-4-nitrophenyl)-2,4-pentadienamide

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm5002277

Reference yield:

: 121-88-0
5-Nitro-2-aminophenol

: 700359-91-7
piperic acid mesylate

: 1313740-72-5
(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-hydroxy-4-nitrophenyl)-2,4-pentadienamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.freeradbiomed.2021.04.026

Reference yield:

: 94-62-2,7780-20-3
Piperine

: 1313740-72-5
(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-hydroxy-4-nitrophenyl)-2,4-pentadienamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 48 h / 20 °C

2: triethylamine / dichloromethane / 45 h / 0 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With triethylamine; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.freeradbiomed.2021.04.026