Technology Process of ethyl (methyl 4-O-benzyl-2,3-O-isopropylidene-6,7-dideoxy-α-D-manno-octo-6E-enopyranosid)uronate
There total 5 articles about ethyl (methyl 4-O-benzyl-2,3-O-isopropylidene-6,7-dideoxy-α-D-manno-octo-6E-enopyranosid)uronate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / NaH; HMPA; TBAI / tetrahydrofuran / 2 h / 23 °C
2: TBAF / tetrahydrofuran / 2 h / 23 °C
3: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 23 °C
4: 503 mg / CH2Cl2 / 5 h / 23 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; oxalyl dichloride; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane;
3: Swern oxidation / 4: Wittig reaction;
DOI:10.1002/anie.200353478
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 23 °C
2: 503 mg / CH2Cl2 / 5 h / 23 °C
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
1: Swern oxidation / 2: Wittig reaction;
DOI:10.1002/anie.200353478
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / NaH; HMPA; TBAI / tetrahydrofuran / 2 h / 23 °C
2: TBAF / tetrahydrofuran / 2 h / 23 °C
3: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - 23 °C
4: 503 mg / CH2Cl2 / 5 h / 23 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; oxalyl dichloride; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane;
3: Swern oxidation / 4: Wittig reaction;
DOI:10.1002/anie.200353478
