292618-32-7 Usage
Uses
Used in Oncology:
ST1481 is used as an anticancer agent for its ability to inhibit the activity of squalene synthase, thereby disrupting the synthesis of cholesterol and other sterols essential for cancer cell growth and proliferation. This mechanism contributes to its potential as a therapeutic option in treating multiple types of cancer, including breast, lung, and prostate cancer.
Used in Drug Development:
In the pharmaceutical industry, ST1481 is utilized as a lead compound for the development of new cancer therapies. Its unique mode of action and demonstrated efficacy in preclinical studies make it a valuable asset in the search for innovative treatments with potential low toxicity profiles for cancer patients.
Used in Preclinical Research:
ST1481 serves as a subject of investigation in preclinical studies aimed at understanding its antitumor activity, mechanism of action, and safety profile. These studies are crucial for advancing the compound towards clinical trials and eventual use in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 292618-32-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,2,6,1 and 8 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 292618-32:
(8*2)+(7*9)+(6*2)+(5*6)+(4*1)+(3*8)+(2*3)+(1*2)=157
157 % 10 = 7
So 292618-32-7 is a valid CAS Registry Number.
InChI:InChI=1/C25H25N3O5/c1-5-25(31)18-10-20-21-16(12-28(20)22(29)17(18)13-32-23(25)30)15(11-26-33-24(2,3)4)14-8-6-7-9-19(14)27-21/h6-11,31H,5,12-13H2,1-4H3/b26-11+/t25-/m0/s1
292618-32-7Relevant academic research and scientific papers
Dallavalle,Ferrari,Biasotti,Merlini,Penco,Gallo,Marzi,Tinti,Martinelli,Pisano,Carminati,Carenini,Beretta,Perego,De Cesare,Pratesi,Zunino
, p. 3264 - 3274 (2001)
In an attempt to synthesize potential anticancer agents acting by inhibition of topoisomerase I (Topo I) a new series of oxyiminomethyl derivatives in position 7 of camptothecin (CPT) was prepared. The synthesis relied on the condensation of 20S-CPT-7-ald
STEREOSELECTIVE PROCESS AND CRYSTALLINE FORMS OF A CAMPTOTHECIN
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Page/Page column 4, (2009/10/01)
A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
