(2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine

Base Information

Chemical Name:(2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine
CAS No.:943348-58-1
Molecular Formula:C₂₇H₂₉NO₄
Molecular Weight:431.532
Hs Code.:

Synonyms:(2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine

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Chemical Property of (2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine

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Technology Process of (2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine

There total 6 articles about (2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 943348-76-3
(2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine

: 74-88-4
methyl iodide

: 943348-58-1
(2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine

Guidance literature:: (2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at -78 - 25 ℃; for 3h; Further stages.;
DOI:10.1021/ja069371r

Reference yield:

: 100-52-7
benzaldehyde

: 943348-58-1
(2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / MgSO₄ / CH₂Cl₂ / 25 °C

2.1: 91 percent / (S)-VAPOL; triphenyl borate / CCl₄ / 24 h / 0 °C

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 91 percent / tetrahydrofuran / 3 h / -78 - 25 °C

With magnesium sulfate; lithium diisopropyl amide; (3S)-(+)-2,2'-diphenyl-(3,3'-biphenanthrene)-4,4'-diol; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/ja069371r

Reference yield:

: 19293-62-0
p,p'-dimethoxybenzhydrylamine

: 943348-58-1
(2R,3R)-cis-1-(N-1-bis(4-methoxyphenyl)methyl)-2-carboxyethyl-3-phenylaziridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / MgSO₄ / CH₂Cl₂ / 25 °C

2.1: 91 percent / (S)-VAPOL; triphenyl borate / CCl₄ / 24 h / 0 °C

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 91 percent / tetrahydrofuran / 3 h / -78 - 25 °C

With magnesium sulfate; lithium diisopropyl amide; (3S)-(+)-2,2'-diphenyl-(3,3'-biphenanthrene)-4,4'-diol; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/ja069371r