N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Base Information

Chemical Name:N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide
CAS No.:1448812-31-4
Molecular Formula:C₂₀H₁₈ClN₅O₂
Molecular Weight:395.848
Hs Code.:

Synonyms:N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

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Technology Process of N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

There total 6 articles about N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5334-43-0
5-Amino-4-cyano-1-phenylpyrazole

: 1448812-08-5
N-(3-chloro-5-formyl-2-hydroxyphenyl)propionamide

: 1448812-31-4
N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / toluene / Reflux

2: lithium borohydride / tetrahydrofuran / 0 - 20 °C

With lithium borohydride; pyridinium p-toluenesulfonate; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2013.06.026

Reference yield:

: C₂₀H₁₆ClN₅O₂

: 1448812-31-4
N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2013.06.026

Reference yield:

: 221291-87-8
N-(3-chloro-2-hydroxyphenyl)propionamide

: 1448812-31-4
N-(3-chloro-5-(((4-cyano-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: hexamethylenetetramine / 130 °C

2: pyridinium p-toluenesulfonate / toluene / Reflux

3: lithium borohydride / tetrahydrofuran / 0 - 20 °C

With lithium borohydride; hexamethylenetetramine; pyridinium p-toluenesulfonate; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2013.06.026