2-methyl-N-(2-(quinazolin-4-yl)hydrazinecarbonothioyl)benzamide

Base Information

• Chemical Name: 2-methyl-N-(2-(quinazolin-4-yl)hydrazinecarbonothioyl)benzamide
• CAS No.: 1394045-56-7
• Molecular Formula: C₁₇H₁₅N₅OS
• Molecular Weight: 337.405
• Mol file: 1394045-56-7.mol

Synonyms:2-methyl-N-(2-(quinazolin-4-yl)hydrazinecarbonothioyl)benzamide

Chemical Property of 2-methyl-N-(2-(quinazolin-4-yl)hydrazinecarbonothioyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-N-(2-(quinazolin-4-yl)hydrazinecarbonothioyl)benzamide

There total 3 articles about 2-methyl-N-(2-(quinazolin-4-yl)hydrazinecarbonothioyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

quinazolin-4-ylhydrazine (36075-44-2) + 2-methylbenzoyl isothiocyanate (28115-85-7) → 2-methyl-N-(2-(quinazolin-4-yl)hydrazinecarbonothioyl)benzamide (1394045-56-7)

Guidance literature:

In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.ejmech.2012.06.003

Reference yield:

4-Hydroxyquinazoline (491-36-1) → 2-methyl-N-(2-(quinazolin-4-yl)hydrazinecarbonothioyl)benzamide (1394045-56-7)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus pentachloride; trichlorophosphate / Reflux

2: hydrazine hydrate / ethanol / 4 h / Reflux

3: 1,4-dioxane / 20 °C

With phosphorus pentachloride; hydrazine hydrate; trichlorophosphate; In 1,4-dioxane; ethanol;

DOI:10.1016/j.ejmech.2012.06.003

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-methyl-N-(2-(quinazolin-4-yl)hydrazinecarbonothioyl)benzamide (1394045-56-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 5 h / 125 - 127 °C

2: phosphorus pentachloride; trichlorophosphate / Reflux

3: hydrazine hydrate / ethanol / 4 h / Reflux

4: 1,4-dioxane / 20 °C

With phosphorus pentachloride; hydrazine hydrate; trichlorophosphate; In 1,4-dioxane; ethanol;

DOI:10.1016/j.ejmech.2012.06.003

upstream raw materials:

4-Hydroxyquinazoline

quinazolin-4-ylhydrazine

2-methylbenzoyl isothiocyanate

anthranilic acid