2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

Base Information

Chemical Name:2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine
CAS No.:1287685-03-3
Molecular Formula:C₂₀H₂₄F₃N₅O₃S
Molecular Weight:471.503
Hs Code.:

Synonyms:2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

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Chemical Property of 2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

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Technology Process of 2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

There total 4 articles about 2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287686-16-1
benzyl 4-(5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazin-2-yl)piperazine-1-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1287685-03-3
2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

Guidance literature:: benzyl 4-(5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazin-2-yl)piperazine-1-carboxylate; With hydrogen; 5% Pd(II)/C(eggshell); In methanol; under 760.051 Torr;

methanesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1287685-03-3
2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,1-dichloroethane / 1 h / 80 °C

1.2: 16 h / 20 °C

1.3: 0 - 20 °C

2.1: caesium carbonate / acetonitrile / 12 h / 80 °C

3.1: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 100 °C / Inert atmosphere

4.1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 760.05 Torr

4.2: 2 h / 0 °C

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5% Pd(II)/C(eggshell); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; 1,1-dichloroethane; toluene; acetonitrile;

Reference yield:

: 1146157-73-4
methanesulfonic acid 1-(4-trifluoromethylbenzyl)azetidin-3-yl ester

: 1287685-03-3
2-(4-(methylsulfonyl)piperazin-1-yl)-5-(1-(4-(trifluoromethyl)benzyl)azetidin-3-yloxy)pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / acetonitrile / 12 h / 80 °C

2.1: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 100 °C / Inert atmosphere

3.1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 760.05 Torr

3.2: 2 h / 0 °C

With hydrogen; caesium carbonate; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5% Pd(II)/C(eggshell); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; toluene; acetonitrile;