tert-butyl 7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

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Chemical Name:tert-butyl 7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate
CAS No.:1447307-14-3
Molecular Formula:C₃₁H₃₈N₄O₂
Molecular Weight:498.668
Hs Code.:

Synonyms:tert-butyl 7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

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Chemical Property of tert-butyl 7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

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Technology Process of tert-butyl 7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

There total 7 articles about tert-butyl 7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 1447306-90-2
tert-butyl 7-acetoxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

: 1447307-14-3
tert-butyl 7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

Guidance literature:: at 20 ℃; Sonication;

Reference yield:

: 2,3-di-p-tolylpyrido[2,3-b]pyrazine

: 1447307-14-3
tert-butyl 7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.13 h / 5 °C / Inert atmosphere

1.2: 20 - 40 °C

2.1: methyl tributylammonium chloride; potassium permanganate / dichloromethane / 0.83 h / 0 - 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 3 h / Reflux

4.1: tri-n-butyl-tin hydride / toluene / 20 °C / Reflux

5.1: pyridine / 20 °C

6.1: 20 °C / Sonication

With pyridine; potassium permanganate; lithium aluminium tetrahydride; tri-n-butyl-tin hydride; methyl tributylammonium chloride; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1356332-98-3
7,8-dihydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-carboxylic acid tert-butyl ester

: 1447307-14-3
tert-butyl 7-(piperidin-1-yl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 3 h / Reflux

2: tri-n-butyl-tin hydride / toluene / 20 °C / Reflux

3: pyridine / 20 °C

4: 20 °C / Sonication

With pyridine; tri-n-butyl-tin hydride; In tetrahydrofuran; toluene;