tert-butyl N-[(3S)-1-methyl-2-oxo-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl N-[(3S)-1-methyl-2-oxo-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-3-yl]carbamate
CAS No.:1444535-91-4
Molecular Formula:C₂₅H₂₆F₃N₃O₄
Molecular Weight:489.494
Hs Code.:

Synonyms:tert-butyl N-[(3S)-1-methyl-2-oxo-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-3-yl]carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl N-[(3S)-1-methyl-2-oxo-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-3-yl]carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl N-[(3S)-1-methyl-2-oxo-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-3-yl]carbamate

There total 7 articles about tert-butyl N-[(3S)-1-methyl-2-oxo-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1444535-74-3
tert-butyl N-[(3S)-1-methyl-2-oxo-3-(prop-2-ynyl)pyrrolidin-3-yl]carbamate

: 1444535-80-1
2-iodo-4-[3-(trifluoromethoxy)phenyl]pyridine

: 1444535-91-4
tert-butyl N-[(3S)-1-methyl-2-oxo-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-3-yl]carbamate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; In tetrahydrofuran; at 20 ℃; for 90h; Inert atmosphere;

Reference yield:

: 1444535-27-6
3-(benzhydrylideneamino)-1-methyl-3-(prop-2-ynyl)pyrrolidin-2-one

: 1444535-91-4
tert-butyl N-[(3S)-1-methyl-2-oxo-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: citric acid / tetrahydrofuran / 18 h / 20 °C

1.2: Ambersep 900(OH) / 1.5 h / 20 °C

2.1: isopropyl alcohol / 3.5 h / 55 - 75 °C

2.2: ambersep-900(OH) / 1 h

3.1: dichloromethane / 5 h / 40 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / tetrahydrofuran / 90 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; citric acid; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

Reference yield:

: 1444535-16-3
3-(benzhydrylidene amino)-1-methyl pyrrolidin-2-one

: 1444535-91-4
tert-butyl N-[(3S)-1-methyl-2-oxo-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran; toluene / 3.5 h / -65 °C / Molecular sieve; Inert atmosphere

2.1: citric acid / tetrahydrofuran / 18 h / 20 °C

2.2: Ambersep 900(OH) / 1.5 h / 20 °C

3.1: semiprep AD-H / ethanol; n-heptane / Resolution of racemate

4.1: dichloromethane / 5 h / 40 °C

5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / tetrahydrofuran / 90 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; diethylamine; citric acid; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; toluene;