(cis)-N,N-diethyl-2,3-dihydro-2-methyl-3-phenyl-2-azetecarboxamide 1-oxide

Base Information

• Chemical Name: (cis)-N,N-diethyl-2,3-dihydro-2-methyl-3-phenyl-2-azetecarboxamide 1-oxide
• CAS No.: 78602-07-0
• Molecular Formula: C₁₅H₂₀N₂O₂
• Molecular Weight: 260.336

Synonyms:(cis)-N,N-diethyl-2,3-dihydro-2-methyl-3-phenyl-2-azetecarboxamide 1-oxide

Chemical Property of (cis)-N,N-diethyl-2,3-dihydro-2-methyl-3-phenyl-2-azetecarboxamide 1-oxide

Chemical Property:

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Technology Process of (cis)-N,N-diethyl-2,3-dihydro-2-methyl-3-phenyl-2-azetecarboxamide 1-oxide

There total 2 articles about (cis)-N,N-diethyl-2,3-dihydro-2-methyl-3-phenyl-2-azetecarboxamide 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2R,3S)-1-Hydroxy-2-methyl-3-phenyl-azetidine-2-carboxylic acid diethylamide (82238-34-4) → (2R,3R)-2-Methyl-1-oxy-3-phenyl-2,3-dihydro-azete-2-carboxylic acid diethylamide (73227-48-2,78602-07-0)

Guidance literature:

With mercury(II) oxide; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(00)87005-7

Reference yield: 35.0%

nitrostyrene (5153-67-3) + methyl(diethylamino)acetylene (4231-35-0) → (cis)-N,N-diethyl-2,3-dihydro-2-methyl-3-phenyl-2-azetecarboxamide 1-oxide (78602-07-0)

Guidance literature:

In acetonitrile; at 15 - 20 ℃; for 3h;

DOI:10.1021/jo00349a004

Reference yield: 93.0%

(cis)-N,N-diethyl-2,3-dihydro-2-methyl-3-phenyl-2-azetecarboxamide 1-oxide (78602-07-0) → N,N-diethyl-1-hydroxy-2-methyl-3-phenyl-2-acetidincarboxamide (82238-34-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 1h;

DOI:10.1021/jo00152a015

upstream raw materials:

(2R,3S)-1-Hydroxy-2-methyl-3-phenyl-azetidine-2-carboxylic acid diethylamide

nitrostyrene

methyl(diethylamino)acetylene

Downstream raw materials:

(2R,3S,4S)-1-Hydroxy-2,4-dimethyl-3-phenyl-azetidine-2-carboxylic acid diethylamide

(2R,3S,4R)-4-Cyano-1-hydroxy-2-methyl-3-phenyl-azetidine-2-carboxylic acid diethylamide

(2R,3S)-1-Hydroxy-2-methyl-3-phenyl-azetidine-2-carboxylic acid diethylamide

(2R,3R)-4-Cyano-2-methyl-1-oxy-3-phenyl-2,3-dihydro-azete-2-carboxylic acid diethylamide

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