5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1427034-96-5
Molecular Formula:C₃₃H₂₅F₂N₇O₅S
Molecular Weight:669.668
Hs Code.:

5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Synonyms:5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 21 articles about 5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1427034-95-4
6-(azidomethyl)-2-chloro-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indole

: 1427034-96-5
5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate; XPhos; In water; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1426942-84-8
6-chloro-2-(4-fluoro-1H-indol-2-yl)pyridin-3-ol

: 1427034-96-5
5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; tin / ethanol / 3 h / Reflux

2: methanesulfonic acid / tetrahydrofuran / 2 h / 50 °C

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 2 h / 80 °C

4: sodium tetrahydroborate / dichloromethane; methanol / 2 h / 20 °C

5: pyridine / 2 h / 0 - 20 °C / Inert atmosphere

6: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

7: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

With pyridine; hydrogenchloride; tin; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; methanesulfonic acid; potassium phosphate tribasic trihydrate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1426942-85-9
6-chloro-2-(4-fluoroindolin-2-yl)pyridin-3-ol

: 1427034-96-5
5-(6-(azidomethyl)-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino [3 ,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: methanesulfonic acid / tetrahydrofuran / 2 h / 50 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 2 h / 80 °C

3: sodium tetrahydroborate / dichloromethane; methanol / 2 h / 20 °C

4: pyridine / 2 h / 0 - 20 °C / Inert atmosphere

5: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

6: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; methanesulfonic acid; potassium phosphate tribasic trihydrate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;