(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Base Information

Chemical Name:(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
CAS No.:1075230-69-1
Molecular Formula:C₁₁H₁₄FN₃S
Molecular Weight:239.317
Hs Code.:

Synonyms:(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

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Technology Process of (S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

There total 9 articles about (S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1075230-68-0
C₁₁H₁₂FN₃O₂S*ClH

: 1075230-69-1
(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: C₁₁H₁₂FN₃O₂S*ClH; With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 18h;

With sodium carbonate; In water;

Reference yield:

: C₁₁H₁₂FN₃O₂S

: 1075230-69-1
(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: With iron; ammonium chloride; In water; toluene; at 80 ℃; for 2h;
DOI:10.1002/cmdc.201900478

Reference yield:

: (S)-N-((2-(2-fluorophenyl)-4-hydroxybutan-2-yl)carbamothioyl)benzamide

: 1075230-69-1
(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 4 h / 0 °C

2: hydrazine hydrate / ethanol / 5 h / 20 °C

3: sulfuric acid; nitric acid / trifluoroacetic acid / 0.42 h / -20 °C

4: ammonium chloride; iron / toluene; water / 2 h / 80 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sulfuric acid; nitric acid; iron; ammonium chloride; hydrazine hydrate; In ethanol; dichloromethane; water; toluene; trifluoroacetic acid;
DOI:10.1002/cmdc.201900478