(R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide

Base Information

• Chemical Name: (R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide
• CAS No.: 1606166-80-6
• Molecular Formula: C₁₂H₁₆FNOS
• Molecular Weight: 241.33
• Mol file: 1606166-80-6.mol

Synonyms:(R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide

Chemical Property of (R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide

There total 1 articles about (R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2'-Fluoroacetophenone (445-27-2) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide (1606166-80-6)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran; at 80 ℃; for 18h;

Reference yield: 97.0%

(R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide (1606166-80-6) + ethyl bromoacetate (105-36-2) → (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate (1432511-81-3)

Guidance literature:

ethyl bromoacetate; With copper(l) chloride; zinc; In tetrahydrofuran; at 50 ℃; for 0.333333h;

(R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide; In tetrahydrofuran; at -30 - 0 ℃; for 2.66667h;

DOI:10.1002/cmdc.201900478

Reference yield: 90.0%

methyl 2-(benzyloxy)acetate (31600-43-8) + (R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide (1606166-80-6) → C22H28FNO4S

Guidance literature:

methyl 2-(benzyloxy)acetate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Molecular sieve;

With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; hexane; at -78 ℃; for 0.916667h;

(R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

upstream raw materials:

2'-Fluoroacetophenone

(R)-2-methylpropane-2-sulfinamide

Downstream raw materials:

C₁₉H₂₅FN₂O₃S

(R)-N-((R)-1-(2-fluorophenyl)ethyl)-2-methylpropane-2-sulfinamide

(R)-1-(2-fluorophenyl)ethanamine hydrochloride