(S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate

Base Information

• Chemical Name: (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate
• CAS No.: 1432511-81-3
• Molecular Formula: C₁₆H₂₄FNO₃S
• Molecular Weight: 329.436
• Mol file: 1432511-81-3.mol

Synonyms:(S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate

Chemical Property of (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate

There total 2 articles about (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide (1606166-80-6) + ethyl bromoacetate (105-36-2) → (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate (1432511-81-3)

Guidance literature:

ethyl bromoacetate; With copper(l) chloride; zinc; In tetrahydrofuran; at 50 ℃; for 0.333333h;

(R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide; In tetrahydrofuran; at -30 - 0 ℃; for 2.66667h;

DOI:10.1002/cmdc.201900478

Reference yield: 84.0%

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluorophenyl)-(E)-ethylidene]amide (1346145-50-3) + ethyl bromoacetate (105-36-2) → (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate (1432511-81-3)

Guidance literature:

ethyl bromoacetate; With copper(l) chloride; zinc; In tetrahydrofuran; at 50 ℃; for 0.5h; Inert atmosphere;

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluorophenyl)-(E)-ethylidene]amide; In tetrahydrofuran; at -20 ℃; Inert atmosphere;

DOI:10.1021/jm400225m

Reference yield: 100.0%

(S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluorophenyl)butanoate (1432511-81-3) → C12H16FNO2

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 0 - 20 ℃; for 0.75h;

DOI:10.1002/cmdc.201900478

upstream raw materials:

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluorophenyl)-(E)-ethylidene]amide

ethyl bromoacetate

(R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide

Downstream raw materials:

(R)-2-methyl-N-((2S,4R)-5,5,5-trifluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinamide

(R)-2-methyl-N-((2S,4S)-5,5,5-trifluoro-2-(2-fluorophenyl)-4-hydroxypentan-2-yl)propane-2-sulfinamide

(4S,6R)-4-(2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

(4S,6R)-4-(2-fluoro-5-nitrophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine