N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate]

Base Information

• Chemical Name: N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate]
• CAS No.: 1293390-77-8
• Molecular Formula: C₅₂H₆₃N₁₀O₁₈P
• Molecular Weight: 1147.1

Synonyms:N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate]

Chemical Property of N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate]

There total 5 articles about N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N2-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O6-[2-(4.nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 5'-[2-(2-nitrophenyl)propyl carbonate] (1293390-70-1) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → N2-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O6-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate] (1293390-77-8)

Guidance literature:

With 1H-tetrazole; In dichloromethane; at 20 ℃; for 22h; Inert atmosphere;

DOI:10.1002/hlca.201000403

Reference yield:

N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>guanosine (148144-85-8) → N2-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O6-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate] (1293390-77-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine / 18 h / 20 °C

2.1: (1S)-10-camphorsulfonic acid / dichloromethane / 18 h / 20 °C / Molecular sieve

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran; water / 0.17 h

4.1: pyridine / dichloromethane / 5 h / -30 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: 1H-tetrazole / dichloromethane / 22 h / 20 °C / Inert atmosphere

With pyridine; 1H-tetrazole; (1S)-10-camphorsulfonic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; water;

DOI:10.1002/hlca.201000403

Reference yield:

4-methoxy-2,6-dihydropyran (17327-22-9) → N2-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O6-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate] (1293390-77-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: (1S)-10-camphorsulfonic acid / dichloromethane / 18 h / 20 °C / Molecular sieve

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran; water / 0.17 h

3.1: pyridine / dichloromethane / 5 h / -30 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: 1H-tetrazole / dichloromethane / 22 h / 20 °C / Inert atmosphere

With pyridine; 1H-tetrazole; (1S)-10-camphorsulfonic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; water;

DOI:10.1002/hlca.201000403

upstream raw materials:

N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4.nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 5'-[2-(2-nitrophenyl)propyl carbonate]

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

4-methoxy-2,6-dihydropyran

N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1293390-77-8 N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate]

Send

Send

Metric Ton KG G Pound L ML

Send

Send