N-(3-methyl-1-(phenylsulfonyl)butyl)-p-toluenesulfonamide

Base Information

• Chemical Name: N-(3-methyl-1-(phenylsulfonyl)butyl)-p-toluenesulfonamide
• CAS No.: 1323310-68-4
• Molecular Formula: C₁₈H₂₃NO₄S₂
• Molecular Weight: 381.517
• Mol file: 1323310-68-4.mol

Synonyms:N-(3-methyl-1-(phenylsulfonyl)butyl)-p-toluenesulfonamide

Chemical Property of N-(3-methyl-1-(phenylsulfonyl)butyl)-p-toluenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-methyl-1-(phenylsulfonyl)butyl)-p-toluenesulfonamide

There total 2 articles about N-(3-methyl-1-(phenylsulfonyl)butyl)-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium benzenesulfonate (873-55-2) + toluene-4-sulfonamide (70-55-3) + isovaleraldehyde (590-86-3) → N-(3-methyl-1-(phenylsulfonyl)butyl)-p-toluenesulfonamide (1323310-68-4)

Guidance literature:

In formic acid; water; at 23 ℃; for 12h; Inert atmosphere;

DOI:10.1002/chem.201101077

Reference yield:

→ N-(3-methyl-1-(phenylsulfonyl)butyl)-p-toluenesulfonamide (1323310-68-4)

Guidance literature:

With formic acid; In water; at 23 ℃; for 12h;

Reference yield: 71.0%

N-(3-methyl-1-(phenylsulfonyl)butyl)-p-toluenesulfonamide (1323310-68-4) + propionaldehyde (123-38-6) → N-((2R,3R)-2,5-dimethyl-1-oxohexan-3-yl)-p-toluenesulfonamide (1323310-58-2)

Guidance literature:

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; sodium hydrogencarbonate; In 1,4-dioxane; at 10 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101077

upstream raw materials:

sodium benzenesulfonate

toluene-4-sulfonamide

isovaleraldehyde

Downstream raw materials:

N-((2R,3R)-2,5-dimethyl-1-hydroxyhexan-3-yl)-p-toluenesulfonamide

N-((2R,3R)-2,5-dimethyl-1-oxohexan-3-yl)-p-toluenesulfonamide

4-methyl-N-[3-methylbutylidene]benzene-1-sulfonamide