4-((1-aminopropan-2-yl)oxy)-3-(benzenesulfonyl)-1,2,5-oxadiazole-2-oxide

Base Information

• Chemical Name: 4-((1-aminopropan-2-yl)oxy)-3-(benzenesulfonyl)-1,2,5-oxadiazole-2-oxide
• CAS No.: 1436851-30-7
• Molecular Formula: C₁₁H₁₃N₃O₅S
• Molecular Weight: 299.307

Synonyms:4-((1-aminopropan-2-yl)oxy)-3-(benzenesulfonyl)-1,2,5-oxadiazole-2-oxide

Chemical Property of 4-((1-aminopropan-2-yl)oxy)-3-(benzenesulfonyl)-1,2,5-oxadiazole-2-oxide

Chemical Property:

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Technology Process of 4-((1-aminopropan-2-yl)oxy)-3-(benzenesulfonyl)-1,2,5-oxadiazole-2-oxide

There total 2 articles about 4-((1-aminopropan-2-yl)oxy)-3-(benzenesulfonyl)-1,2,5-oxadiazole-2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.7%

→ 4-((1-aminopropan-2-yl)oxy)-3-(benzenesulfonyl)-1,2,5-oxadiazole-2-oxide (1436851-30-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 1h; Cooling with ice;

Reference yield:

3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (66074-00-8) + 3-amino-2-propanol (78-96-6,1674-56-2) → 4-((1-aminopropan-2-yl)oxy)-3-(benzenesulfonyl)-1,2,5-oxadiazole-2-oxide (1436851-30-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.cclet.2013.03.006

Reference yield: 85.0%

2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)-amino)-3-methoxyphenyl)piperazin-1-yl)acetic acid (1436851-29-4) + 4-((1-aminopropan-2-yl)oxy)-3-(benzenesulfonyl)-1,2,5-oxadiazole-2-oxide (1436851-30-7) → C37H38ClN9O9S (1436851-35-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm400463q

upstream raw materials:

3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

3-amino-2-propanol

Downstream raw materials:

C₃₇H₃₈ClN₉O₉S

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