3-Butyn-1-ol, 4-[4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-

Base Information

• Chemical Name: 3-Butyn-1-ol, 4-[4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-
• CAS No.: 1173657-02-7
• Molecular Formula: C₁₇H₁₃ClN₂O₃S
• Molecular Weight: 360.821
• Mol file: 1173657-02-7.mol

Synonyms:4-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)but-3-yn-1-ol

Chemical Property of 3-Butyn-1-ol, 4-[4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Butyn-1-ol, 4-[4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-

There total 1 articles about 3-Butyn-1-ol, 4-[4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-chloro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (940948-30-1) + 3-Butyn-1-ol (927-74-2) → 4-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)but-3-yn-1-ol (1173657-02-7)

Guidance literature:

With copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine; In water; at 80 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2009.04.054

Reference yield: 65.0%

4-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)but-3-yn-1-ol (1173657-02-7) + phenylboronic acid (98-80-6) → C23H18N2O3S (1173657-12-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.04.054

upstream raw materials:

4-chloro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

3-Butyn-1-ol

Downstream raw materials:

C₂₃H₁₈N₂O₃S