940948-30-1

Basic information

• Product Name: 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole
• Synonyms: 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole;1-Benzenesulfonyl-4-chlor...;1-(benzenesulfonyl)-4-chloro-2-iodo-1H-pyrrolo[2,3-b]pyridine;4-chloro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;1-(Benzenesulfonyl)-4-chloro-2-iodo-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-1-(phenylsulfonyl)-;1-(Phenylsulphonyl)-4-chloro-2-iodo-7-azaindole;1-(phenylsulfonyl)-4-chloro-2-iodo-7-azaindole
• CAS NO: 940948-30-1
• Molecular Formula: C₁₃H₈ClIN₂O₂S
• Molecular Weight: 418.637
• Product Categories: Azaindoles
• Mol File: 940948-30-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 135 °C
• Boiling Point: 541°C at 760 mmHg
• Flash Point: 281°C
• Appearance: /
• Density: 1.91g/cm³
• Vapor Pressure: 9.03E-12mmHg at 25°C
• Refractive Index: 1.745
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.20±0.30(Predicted)
• CAS DataBase Reference: 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole(940948-30-1)
• EPA Substance Registry System: 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole(940948-30-1)

Safety Data

• Hazardous Substances Data: 940948-30-1(Hazardous Substances Data)

Usage

General Description

1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole is a chemical compound with a complex structure. It consists of a benzene ring with a sulfonyl group attached, as well as a chlorine and iodine atom at specific positions on a 7-azaindole ring. 1-Benzenesulfonyl-4-chloro-2-iodo-7-azaindole is used in the synthesis of pharmaceuticals and agrochemicals due to its unique structure and reactivity. It has been studied for its potential use in drug development and as a building block in organic synthesis. Additionally, it may also have applications in the field of materials science and chemical research.

InChI:InChI=1/C13H8ClIN2O2S/c14-11-6-7-16-13-10(11)8-12(15)17(13)20(18,19)9-4-2-1-3-5-9/h1-8H

Upstream product

• 744209-63-0 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1173657-06-1 5-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)pent-4-yn-2-ol 
• 1173657-08-3 6-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)hex-5-ynenitrile 
• 1173657-05-0 5-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)pent-4-yn-1-ol 
• 1173657-11-8 3-((4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)ethynyl)aniline 
• 1173657-07-2 1-((4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)ethynyl)cyclohexanol 
• 1173657-09-4 4-chloro-2-(phenylethynyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1173657-03-8 4-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)but-3-yn-2-ol 
• 1173657-04-9 4-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-methylbut-3-yn-2-ol 
• 1173657-02-7 4-(4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)but-3-yn-1-ol 
• 1173657-10-7 4-chloro-1-(phenylsulfonyl)-2-(p-tolylethynyl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE

This invention relates to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular,the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

A highly effective synthesis of 2-alkynyl-7-azaindoles: Pd/C-mediated alkynylation of heteroaryl halides in water

The reaction of 4-chloro-2-iodo-7-azaindole with terminal alkynes was investigated using 10% Pd/C-PPh3-CuI as a catalyst system in water. This study afforded a new, mild and selective process for the preparation of 2-alkynyl-4-chloro-7-azaindole in good yields via C-C bond forming reaction. The resulting chloro derivative can be functionalized further via another Pd-mediated C-C bond forming reaction?with arylboronic acid.