Ethylazidoformate

Base Information

• Chemical Name: Ethylazidoformate
• CAS No.: 817-87-8
• Molecular Formula: C₃H₅N₃O₂
• Molecular Weight: 115.092
• Mol file: 817-87-8.mol

Synonyms:Ethylazidoformate

Chemical Property of Ethylazidoformate

Chemical Property:

• Refractive Index: 1.4500 (estimate)
• Boiling Point: 215.34°C (rough estimate)
• PSA: 76.05000
• Density: 1.4923 (rough estimate)
• LogP: 0.90596

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s): 3
• Hazard Codes: 3

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethylazidoformate

There total 7 articles about Ethylazidoformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

chloroformic acid ethyl ester (541-41-3) → ethyl azidocarbonate (817-87-8)

Guidance literature:

With sodium azide; In diethyl ether; water; at 20 ℃; Cooling with ice;

DOI:10.1016/j.tetlet.2013.07.135

Reference yield:

N,N-Dimethylhydrazine (57-14-7) + diethylazodicarboxylate (1972-28-7,218603-74-8) → ethyl N,N-dimethylcarbamate (687-48-9) + Tetramethyltetrazon (6130-87-6) + ethyl azidocarbonate (817-87-8) + diethyl hydrazodicarboxylate (4114-28-7)

Guidance literature:

In tetrachloromethane; for 0.25h; Mechanism; Product distribution; Ambient temperature; diethyl azodicarboxylate was added to hydrazine derivate; using also two other hydrazine derivates;

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) → ethyl azidocarbonate (817-87-8)

Guidance literature:

With sodium nitrite; In dichloromethane; water; at 18 - 20 ℃;

DOI:10.1021/acs.orglett.1c02071

upstream raw materials:

chloroformic acid ethyl ester

ethylhydrazine carboxylate

N,N-Dimethylhydrazine

diethylazodicarboxylate

Downstream raw materials:

N'-phenyl-triazene carboxylic acid ethylester

3,3-dioxo-3λ⁶-thia-6-aza-bicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester

1,2-Bis-ethoxycarbonylimino-1,2-diphenyl-ethan

5-Carbethoxyamino-cyclohexadien-(1,3)

Refernces

• 1、 Belloli et al.. "". . p. 1857. Retrieved 1972.
• 2、 Baykal, Aslihan,Zhang, Dihan,Knelles, Jakob,Alt, Isabel T.,Plietker, Bernd. "Nucleophilic Iron Complexes in Proton-Transfer Catalysis: An Iron-Catalyzed Dimroth Cyclocondensation". supporting information. p. 3003 - 3010. Retrieved 2019/08/21.
• 3、 Das, Debapratim,Samanta, Rajarshi. "Iridium(III)-Catalyzed Regiocontrolled Direct Amidation of Isoquinolones and Pyridones". supporting information. p. 379 - 384. Retrieved 2017/12/26.