N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}seryl]-(S)-isoleucine benzyl ester

Base Information

Chemical Name:N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}seryl]-(S)-isoleucine benzyl ester
CAS No.:623562-55-0
Molecular Formula:C₃₅H₄₈N₄O₈
Molecular Weight:652.788
Hs Code.:

Synonyms:N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}seryl]-(S)-isoleucine benzyl ester

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Chemical Property of N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}seryl]-(S)-isoleucine benzyl ester

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Technology Process of N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}seryl]-(S)-isoleucine benzyl ester

There total 1 articles about N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}seryl]-(S)-isoleucine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 180078-23-3
9S-isopropyl-7,10-dioxo-2-oxa-8,11-diaza-bicyclo[12.2.2]octadeca-1⁽¹⁷⁾,14⁽¹⁸⁾,15-triene-12S-carboxylic acid

: N-[(S)-seryl]-(S)-isoleucine benzyl ester trifluoroacetic acid salt

: 623562-55-0
N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}seryl]-(S)-isoleucine benzyl ester

Guidance literature:: 9S-isopropyl-7,10-dioxo-2-oxa-8,11-diaza-bicyclo[12.2.2]octadeca-1⁽¹⁷⁾,14⁽¹⁸⁾,15-triene-12S-carboxylic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

N-[(S)-seryl]-(S)-isoleucine benzyl ester trifluoroacetic acid salt; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1039/b211644h

Reference yield:

: 623562-55-0
N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}seryl]-(S)-isoleucine benzyl ester

: 623562-57-2
C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine

Guidance literature:: Multi-step reaction with 3 steps

1: 4 Angstroem molecular sieves / ethyl acetate / 75 °C

2: 60 mg / Et₃N / CH₂Cl₂ / 48 h / Heating

3: 89 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran / 12 h / 20 °C

With 4 A molecular sieve; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1039/b211644h

Reference yield:

: 623562-55-0
N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}seryl]-(S)-isoleucine benzyl ester

: (2S,3S)-2-{2-[4-(3-Amino-propoxy)-phenylamino]-2-[((9S,12S)-9-isopropyl-7,10-dioxo-2-oxa-8,11-diaza-bicyclo[12.2.2]octadeca-1⁽¹⁷⁾,14⁽¹⁸⁾,15-triene-12-carbonyl)-amino]-acetylamino}-3-methyl-pentanoic acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 4 Angstroem molecular sieves / ethyl acetate / 75 °C

2: 60 mg / Et₃N / CH₂Cl₂ / 48 h / Heating

3: 89 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran / 12 h / 20 °C

4: 90 percent / HCl / diethyl ether / 6 h / 20 °C

With hydrogenchloride; 4 A molecular sieve; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1039/b211644h