C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine

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Chemical Name:C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine
CAS No.:623562-57-2
Molecular Formula:C₄₁H₆₀N₆O₁₀
Molecular Weight:796.962
Hs Code.:

C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine

Synonyms:C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine

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Chemical Property of C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine

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Technology Process of C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine

There total 6 articles about C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 623562-57-2
C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / PPh₃; DEAD / tetrahydrofuran / 20 °C

2: 89 percent / H₂ / 10 percent Pd/C / methanol / 6 h

3: 60 mg / Et₃N / CH₂Cl₂ / 48 h / Heating

4: 89 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran / 12 h / 20 °C

With hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b211644h

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 623562-57-2
C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / PPh₃; DEAD / tetrahydrofuran / 20 °C

2: 89 percent / H₂ / 10 percent Pd/C / methanol / 6 h

3: 60 mg / Et₃N / CH₂Cl₂ / 48 h / Heating

4: 89 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran / 12 h / 20 °C

With hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b211644h

Reference yield:

: 623562-56-1
1-amino-4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]benzene

: 623562-57-2
C-{[4-[3-[N-(tert-butoxycarbonyl)amino]propan-1-yloxy]phenyl]amino}-N-[N-{(9S,12S)-7,10-dioxo-9-isopropyl-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-14,16,17-trien-12-ylcarbonyl}glycyl]-(S)-isoleucine

Guidance literature:: Multi-step reaction with 2 steps

1: 60 mg / Et₃N / CH₂Cl₂ / 48 h / Heating

2: 89 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran / 12 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/b211644h