rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone

Base Information

Chemical Name:rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone
CAS No.:95455-17-7
Molecular Formula:C₂₅H₃₅NO₂Si
Molecular Weight:409.644
Hs Code.:

Synonyms:rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone

Suppliers and Price of rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone

There total 5 articles about rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 88996-00-3
5-iodo-1-(trimethylsilyl)-2-pentyne

: 95455-15-5
rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-1-isoindolone

: 95455-17-7
rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;
DOI:10.1016/S0040-4020(01)86638-2

Reference yield:

: 66050-03-1
cis-2-benzyl-1,3,3a,4,7,7a-hexahydro-1,3-isoindoledione

: 95455-17-7
rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / sodium borohydride, 2 M HCl / 4 h / 0 - 5 °C

2: 55 percent / LDA / tetrahydrofuran / 2 h / -78 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)86638-2

Reference yield:

: 100-44-7
benzyl chloride

: 95455-17-7
rel-(3R,3aS,7aR)-2-benzyl-3-ethoxy-2,3,3a,4,7,7a-hexahydro-7a-<5-(trimethylsilyl)-3-pentynyl>-1-isoindolone

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / acetone

2: 1.) NaBH₄

3: 1.) LDA / 1.) THF, -78 deg C, 30 min. 2.) -78 to 0 deg C

With sodium tetrahydroborate; potassium carbonate; lithium diisopropyl amide; In acetone;
DOI:10.1016/S0040-4039(01)91310-3