(2S,6R)-6-Amino-2-((R)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-hydrazinocarbonyl-hexanoic acid

Base Information

Chemical Name:(2S,6R)-6-Amino-2-((R)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-hydrazinocarbonyl-hexanoic acid
CAS No.:79336-02-0
Molecular Formula:C₂₀H₂₉N₅O₈
Molecular Weight:467.479
Hs Code.:

Synonyms:(2S,6R)-6-Amino-2-((R)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-hydrazinocarbonyl-hexanoic acid

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Chemical Property of (2S,6R)-6-Amino-2-((R)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-hydrazinocarbonyl-hexanoic acid

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Technology Process of (2S,6R)-6-Amino-2-((R)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-hydrazinocarbonyl-hexanoic acid

There total 5 articles about (2S,6R)-6-Amino-2-((R)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-hydrazinocarbonyl-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80226-11-5
(2S,6R)-2-Amino-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

: 79336-02-0
(2S,6R)-6-Amino-2-((R)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-hydrazinocarbonyl-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran; dimethylformamide / Ambient temperature

2: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) CH₂Cl₂, from -15 to -10 deg C, 2.) from -10 to 0 deg C

3: 1 N aq. NaOH / methanol

4: trifluoroacetic acid / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00346a001

Reference yield:

: 94271-26-8
C₂₀H₄₀N₄O₇Si

: 79336-02-0
(2S,6R)-6-Amino-2-((R)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-hydrazinocarbonyl-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) CH₂Cl₂, from -15 to -10 deg C, 2.) from -10 to 0 deg C

2: 1 N aq. NaOH / methanol

3: trifluoroacetic acid / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; trifluoroacetic acid; isobutyl chloroformate; In methanol;
DOI:10.1021/jm00346a001

Reference yield:

: 79336-01-9
(2S,6R)-2-((R)-4-Benzyloxycarbonyl-4-benzyloxycarbonylamino-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

: 79336-02-0
(2S,6R)-6-Amino-2-((R)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-hydrazinocarbonyl-hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1 N aq. NaOH / methanol

2: trifluoroacetic acid / Ambient temperature

With sodium hydroxide; trifluoroacetic acid; In methanol;
DOI:10.1021/jm00346a001