(2S,6R)-2-((R)-4-Benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

Base Information

Chemical Name:(2S,6R)-2-((R)-4-Benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid
CAS No.:79358-64-8
Molecular Formula:C₃₀H₄₅N₅O₁₂
Molecular Weight:667.714
Hs Code.:

(2S,6R)-2-((R)-4-Benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

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Chemical Property of (2S,6R)-2-((R)-4-Benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

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Technology Process of (2S,6R)-2-((R)-4-Benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

There total 4 articles about (2S,6R)-2-((R)-4-Benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79336-01-9
(2S,6R)-2-((R)-4-Benzyloxycarbonyl-4-benzyloxycarbonylamino-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

: 79358-64-8
(2S,6R)-2-((R)-4-Benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1021/jm00346a001

Reference yield:

: 80226-11-5
(2S,6R)-2-Amino-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

: 79358-64-8
(2S,6R)-2-((R)-4-Benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; dimethylformamide / Ambient temperature

2: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) CH₂Cl₂, from -15 to -10 deg C, 2.) from -10 to 0 deg C

3: 1 N aq. NaOH / methanol

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00346a001

Reference yield:

: 94271-26-8
C₂₀H₄₀N₄O₇Si

: 79358-64-8
(2S,6R)-2-((R)-4-Benzyloxycarbonylamino-4-carboxy-butyrylamino)-6-tert-butoxycarbonylamino-7-(N'-tert-butoxycarbonyl-hydrazino)-7-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) CH₂Cl₂, from -15 to -10 deg C, 2.) from -10 to 0 deg C

2: 1 N aq. NaOH / methanol

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate; In methanol;
DOI:10.1021/jm00346a001