(R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline

Base Information

• Chemical Name: (R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline
• CAS No.: 1221687-25-7
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.305
• Mol file: 1221687-25-7.mol

Synonyms:(R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline

Chemical Property of (R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline

There total 4 articles about (R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one (16208-17-6) + 1,2-diamino-benzene (95-54-5) → (R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline (1221687-25-7)

Guidance literature:

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diylhydrogenphosphate; Hantzsch ester; In chloroform; at 35 ℃; for 24h; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/adsc.201300576

Reference yield: 96.0%

3-(4-methoxy-phenyl)-1,2-dihydro-quinoxaline (5021-39-6) → (R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline (1221687-25-7)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; iodine; (((1R,3S,3'S)-3,3'-diethyl-3H,3'H-1,1'-spirobi[isobenzofuran]-7,7'-diyl)bis(oxy))bis(diphenylphosphane); In tetrahydrofuran; at 20 ℃; for 10h; under 18100.7 Torr; enantioselective reaction; Inert atmosphere;

DOI:10.1039/d0cc03088k

Reference yield:

2-(4-methoxyphenyl)quinoxaline (5021-46-5) → (R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline (1221687-25-7) + (S)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroquinoxaline (1253208-06-8)

Guidance literature:

With phenanthridine; diiodo(p-cymene)ruthenium(II) dimer; C₃₄H₃₃O₄P; hydrogen; In benzene; at 20 ℃; for 48h; under 5171.62 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;

DOI:10.1021/ja211684v

upstream raw materials:

2-(4-methoxyphenyl)quinoxaline

2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one

1,2-diamino-benzene

3-(4-methoxyphenyl)quinoxalin-2(1H)-one