5021-46-5

Basic information

• Product Name: 2-(4-methoxyphenyl)quinoxaline
• Synonyms: 2-(p-Methoxyphenyl)quinoxaline; quinoxaline, 2-(4-methoxyphenyl)-; Quinoxaline, 2-(p-methoxyphenyl)-
• CAS NO: 5021-46-5
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.2686
• Mol File: 5021-46-5.mol
• Article Data: 75

Chemical Properties

• Boiling Point: 397.6°C at 760 mmHg
• Flash Point: 132.9°C
• Density: 1.185g/cm³
• Vapor Pressure: 3.59E-06mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: 2-(4-methoxyphenyl)quinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)quinoxaline(5021-46-5)
• EPA Substance Registry System: 2-(4-methoxyphenyl)quinoxaline(5021-46-5)

Safety Data

• Hazardous Substances Data: 5021-46-5(Hazardous Substances Data)

Usage

Structure

Quinoxaline derivative with a methoxy group attached to the phenyl ring

Biological activities

Antioxidant, antitumor, and antibacterial properties

Potential use

Development of new pharmaceutical drugs

Investigated for treatment of

Cancer, diabetes, and microbial infections

Promise

Various medical and therapeutic applications

Upstream product

• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
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• 95-54-5 1,2-diamino-benzene 
• 80336-72-7 2-iodo-1-(4-methoxyphenyl)ethanone 
• 768-60-5 4-methoxyphenylacetylen 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 91-19-0 2,3-diethynylquinoxaline 
• 104-94-9 4-methoxy-aniline 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 615-43-0 2-iodophenylamine 
• 1017266-40-8 C₉H₁₂OZn 
• 265999-47-1 α-(diiodomethyl)-4-methoxybenzenemethanol 
• 1374568-26-9 2,2-diiodo-1-(4-methoxyphenyl)ethanone 
• 1448-87-9 2-chloroquinoxaline 

Downstream Products

• 1444302-44-6 2-(2-fluoro-4-methoxyphenyl)quinoxaline 
• 1444302-13-9 2-(2-fluorophenyl)quinoxaline 
• 1420295-58-4 2-(dimethoxymethyl)-3-(4-methoxyphenyl)quinoxaline 
• 10166-78-6 2-(4-methoxyphenyl)-3-phenylquinoxaline 
• 1221687-25-7 (R)-1,2,3,4-tetrahydro-2-(4-methoxyphenyl)quinoxaline 
• 1253208-06-8 (S)-2-(4-methoxyphenyl)-1,2,3,4-tetrahydroquinoxaline 
• 1262801-86-4 2-(4-methoxy-2-nitrophenyl)quinoxaline 

Relevant articles and documents

Mechanically induced transition metal free C(sp2)-H arylation of quinoxalin(on)es with diaryliodonium salts and piezoelectric BaTiO3

A transition metal free mechanically induced C(sp2)-H arylation of quinoxalin(on)es is described. In this study, diaryliodonium salts generate aryl radical by planetary ball milling, with the assist of piezoelectric material BaTiO3. A broad range of functional groups are tolerated to give products in moderate to good yields via radical mechanism.

A heterogeneous catalytic strategy for facile production of benzimidazoles and quinoxalines from primary amines using the Al-MCM-41 catalyst

This study reports a straightforward heterogeneous catalytic (Al-MCM-41) approach to synthesize nitrogen heterocycle moieties from primary amines under solvent-free conditions. The Al-MCM-41 catalyst was prepared using a hydrothermal method and characterized by various analytical techniques. The probability and limitations of the catalytic methodology were presented with various substrates. The catalytic method grants an attractive route to a wide variety of benzimidazole and quinoxaline moieties with good to excellent yields. The gram scale reaction and reusability (up to five cycles) of the Al-MCM-41 catalyst would greatly benefit industrial applications. This journal is

Iridium-Catalyzed [4+2] Annulations of β-Keto Sulfoxonium Ylides and o-Phenylenediamines: Mild and Facile Synthesis of Quinoxaline Derivatives

A synthetic method for quinoxaline derivatives from the [4+2] annulation of β-keto sulfoxonium ylides and o-phenylenediamine by using (Cp*IrCl2)2 catalyst is described. This novel protocol features mild reaction conditions, moderate to excellent yields, wide substrate scope, and high functional-group compatibility. Moreover, this cyclization strategy was successfully applied in late-stage modification for structurally complex bioactive compounds.